Tablets 2.5mg and 1.5mg MR
First line diuretic for hypertension

Tablets 2.5mg, 5mg

Tablets 2.5mg, 5mg

Treatment of patients with chronic heart failure with resistant volume overload

Must be prescribed by brand

Use the licensed preparation for new patients.

Before requesting primary care prescribing, patients must be established on a stable dose of metolazone for at least 2 weeks, with stable urea and electrolytes (including creatinine) and a stable body weight before discharge.

Ongoing monitoring of urea and electrolytes (including creatinine) should be carried out on a monthly basis and the patients’ weight and blood pressure should be monitored at each clinic visit.

Metolazone has an established role in the treatment of resistant oedema in heart failure where it is combined with a loop diuretic. The combination of metolazone and a loop diuretic is much more potent and needs to be initiated by someone experienced in its use and needs careful monitoring of renal function and electrolytes. It is routinely used in patients with renal impairment who do not respond to a loop diuretic.