Lancashire and South Cumbria
Formulary
Formulary
2 Cardiovascular system
02-06-04 Peripheral vasodilators and related drugs
| Nifedipine |
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Formulary
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M/R Tablets 10mg, 20mg (prescribe modified-release preparations by brand)
Capsules 5mg, 10mg, 20mg (use of immediate-release capsules may be associated with large variations in blood pressure and reflex tachycardia)
Nifedipine is no longer recommended for the treatment of angina or hypertension (except for hypertension in pregnancy, in line with NG133).
Refer to the individual SPC for each preparation of nifedipine for further details on use in preganancy.
Nifedipine is used in Raynaud's syndrome (modified release preparations - unlicensed use).
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 NICE NG133: Hypertension in pregnancy: diagnosis and management |
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| Naftidrofuryl oxalate |
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Formulary
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Capsules 100mg |
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NICE TA223- Cilostazol, naftidrofuryl oxalate, pentoxifylline and inositol nicotinate for the treatment of intermittent claudication in people with peripheral arterial disease |
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| Iloprost (IV) |
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Formulary
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Raynauds Specialist use only |
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LSCMMG - Iloprost (IV) |
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| Iloprost nebuliser solution |
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Formulary
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Pulmonary hypertension For use by specialist centres only. |
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NHSE: high cost drugs commissioning list |
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| Sildenafil |
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Formulary
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Tablets 25mg Digital ulceration Unlicensed indication - Specialist initiation only |
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MHRA: Sildenafil (Revatio and Viagra): reports of persistent pulmonary hypertension of the newborn (PPHN) following in-utero exposure in a clinical trial on intrauterine growth restriction NICE: Digital ulcers: sildenafil |
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| Epoprostenol |
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Formulary
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Injection 500micrograms
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MHRA: Veletri (epoprostenol) powder for solution for infusion: incompatibilities with some models of administration devices |
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Restricted drug - specialist initiation only. 
Unlicensed use.| Cilostazol |
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Formulary
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NICE TA223- Cilostazol, naftidrofuryl oxalate, pentoxifylline and inositol nicotinate for the treatment of intermittent claudication in people with peripheral arterial disease |
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Links
Enoxaparin Shared Care Guideline **FOR USE IN THE MORECAMBE BAY REGION ONLY**- Low Molecular Weight Heparins - Use in Primary care Best Practice Guideline *FOR USE IN PENNINE REGION ONLY*
- LSCMMG - Iloprost (IV)
- LSCMMG: Atrial Fibrillation Pathway for the prevention of stroke and systemic embolism in AF in the absence of valvular heart disease
- LSCMMG: Heart Failure - Primary Care Guideline for the Use of SGLT-2 Inhibitors in Reduced Ejection Fraction Heart Failure
- LSCMMG: Lipid Management Pathway for Primary Prevention of Cardiovascular Disease
- LSCMMG: Lipid Management Pathway for Secondary Prevention of Cardiovascular Disease
- LSCMMG: Low Molecular Weight Heparins (LMWHs) Summary Prescribing Guide
- MHRA Drug Safety Update Nov 18: Sildenafil (Revatio and Viagra): reports of persistent pulmonary hypertension of the newborn (PPHN) following in-utero exposure in a clinical trial on intrauterine growth restriction
- MHRA: Cilostazol (Pletal) - Risks of cardiovascular and bleeding events
- MHRA: Clopidogrel and proton pump inhibitors: interaction—updated advice
- MHRA: Sildenafil (Revatio and Viagra): reports of persistent pulmonary hypertension of the newborn (PPHN) following in-utero exposure in a clinical trial on intrauterine growth restriction
- MHRA: Veletri (epoprostenol) powder for solution for infusion: incompatibilities with some models of administration devices
- NG 185 - Acute coronary syndromes
- NG 196 - Atrial fibrillation: diagnosis and management
- NHSE: high cost drugs commissioning list
- NICE CG147: Lower limb peripheral arterial disease management
- NICE ESOUM42: Digital ulcers: sildenafil
- NICE NG106: Chronic heart failure in adults: diagnosis and management
- NICE NG133: Hypertension in pregnancy: diagnosis and management
- NICE NG136: Hypertension in adults: diagnosis and management
- NICE NG167: COVID-19 rapid guideline: rheumatological autoimmune, inflammatory and metabolic bone disorders
- NICE NG187: Acute heart failure: diagnosis and management
- NICE NG203: Chronic kidney disease: assessment and management
- NICE NG95: Recent-onset chest pain of suspected cardiac origin: assessment and diagnosis
- NICE TA223- Cilostazol, naftidrofuryl oxalate, pentoxifylline and inositol nicotinate for the treatment of intermittent claudication in people with peripheral arterial disease
- NICE TA223- Cilostazol, naftidrofuryl oxalate, pentoxifylline and inositol nicotinate for the treatment of intermittent claudication in people with peripheral arterial disease
- NICE TA223- Cilostazol, naftidrofuryl oxalate, pentoxifylline and inositol nicotinate for the treatment of intermittent claudication in people with peripheral arterial disease
- NICE TA223: Intermittent claudication drugs
- NICE: Digital ulcers: sildenafil