Lancashire and South Cumbria
Formulary
 
back
2 Cardiovascular system
02-08-02 Oral anticoagulants



Edoxaban
Formulary

tablets 15mg, 30mg, 60mg
 
Green Traffic Light Edoxaban for preventing stroke and systemic embolism in people with non-valvular atrial fibrillation (NICE TA355)

Amber 0 Edoxaban for treating and for preventing deep vein thrombosis and pulmonary embolism (NICE TA354)   (Green East Lancashire only, for this indication)

Link  NICE TA354: Edoxaban for treating and for preventing deep vein thrombosis and pulmonary embolism
Link  NICE TA355: Edoxaban for preventing stroke and systemic embolism in people with non-valvular atrial fibrillation

View adult BNF  View SPC online  View childrens BNF
Rivaroxaban Xarelto®
Formulary

Tablets 2.5mg, 10mg, 15mg, 20mg

Green  Rivaroxaban for the prevention of stroke and systemic embolism in people with atrial fibrillation (NICE TA256)
 
Red Rivaroxaban for the prevention of venous thromboembolism after total hip or total knee replacement in adults (NICE TA 170)


Amber 0 Rivaroxaban for preventing adverse outcomes after acute management of acute coronary syndrome (NICE TA335) (Green East Lancashire only, for this indication)

Amber 0 Rivaroxaban for the treatment of deep vein thrombosis and prevention of recurrent deep vein thrombosis and pulmonary embolism (NICE TA261)  (Green East Lancashire only, for this indication)

Amber 0 Rivaroxaban for treating pulmonary embolism and preventing recurrent venous thromboembolism (NICE TA287)  (Green East Lancashire only, for this indication)

 

Amber 0 *10mg tablets* Treatment of DVT and PE, and extended prevention of recurrent DVT and PE in adults

Link  LSCMMG: Rivaroxaban 10mg tablets
Link  MHRA: Rivaroxaban (Xarelto▼) after transcatheter aortic valve replacement: increase in all-cause mortality, thromboembolic and bleeding events in a clinical trial
Link  MHRA: Rivaroxaban (Xarelto▼): reminder that 15 mg and 20 mg tablets should be taken with food
Link  NICE TA170: Rivaroxaban for the prevention of venous thromboembolism after total hip or total knee replacement in adults
Link  NICE TA256: Rivaroxaban for the prevention of stroke and systemic embolism in people with atrial fibrillation
Link  NICE TA261: Rivaroxaban for the treatment of deep vein thrombosis and prevention of recurrent deep vein thrombosis and pulmonary embolism
Link  NICE TA287: Rivaroxaban for treating pulmonary embolism and preventing recurrent venous thromboembolism
Link  NICE TA335: Rivaroxaban for preventing adverse outcomes after acute management of acute coronary syndrome

View adult BNF  View SPC online  View childrens BNF
Apixaban
Formulary

Tablets 2.5mg, 5mg

Green Traffic Light  Apixaban for preventing stroke and systemic embolism in people with non-valvular atrial fibrillation (NICE TA275)


Red Apixaban for the prevention of venous thromboembolism after total hip or knee replacement in adults (NICE TA245)

Amber 0 Apixaban for the treatment and secondary prevention of deep vein thrombosis and/or pulmonary embolism (NICE TA341)

Link  NICE TA245: Apixaban for the prevention of venous thromboembolism after total hip or knee replacement in adults
Link  NICE TA275: Apixaban for preventing stroke and systemic embolism in people with non-valvular atrial fibrillation
Link  NICE TA341: Apixaban for the treatment and secondary prevention of deep vein thrombosis and/or pulmonary embolism

View adult BNF  View SPC online  View childrens BNF
Dabigatran Pradaxa®
Formulary

Capsules 110mg, 150mg

Green Traffic Light Dabigatran etexilate for the prevention of stroke and systemic embolism in atrial fibrillation (NICE TA249)

Red Dabigatran etexilate for the prevention of venous thromboembolism after hip or knee replacement surgery in adults (NICE TA157)

Amber 0  Dabigatran etexilate for the treatment and secondary prevention of deep vein thrombosis and/or pulmonary embolism (NICE TA327)   (Green East Lancashire only, for this indication)

Link  MHRA: Dabigatran (Pradaxa): contraindicated in patients with prosthetic heart valve(s) requiring anti-coagulant treatment
Link  NICE TA157: Dabigatran etexilate for the prevention of venous thromboembolism after hip or knee replacement surgery in adults
Link  NICE TA249: Dabigatran etexilate for the prevention of stroke and systemic embolism in atrial fibrillation
Link  NICE TA327: Dabigatran etexilate for the treatment and secondary prevention of deep vein thrombosis and/or pulmonary embolism

View adult BNF  View SPC online  View childrens BNF
Rivaroxaban with aspirin
Formulary

Tablets 2.5mg

Prevention of cardiac events in patients with coronary (CAD) or peripheral artery Disease (PAD)

 

Amber 0  East Lancashire only

Link  LSCMMG: Rivaroxaban with aspirin
Link  MHRA: Rivaroxaban (Xarelto▼) after transcatheter aortic valve replacement: increase in all-cause mortality, thromboembolic and bleeding events in a clinical trial
Link  MHRA: Rivaroxaban (Xarelto▼): reminder that 15 mg and 20 mg tablets should be taken with food
Link  NICE TA607: Rivaroxaban for preventing atherothrombotic events in people with coronary or peripheral artery disease

Green View adult BNF  View SPC online  View childrens BNF
Warfarin
Formulary

Tablets 1mg, 3mg, 5mg


Amber 0 Treatment of venous thromboembolism

Green Restricted Prevention of stroke and systemic embolism in non-valvular atrial fibrillation

Link  LSCMMG: Atrial Fibrillation
Link  MHRA: Direct-acting antivirals to treat chronic hepatitis C: risk of interaction with vitamin K antagonists and changes in INR
Link  MHRA: Warfarin: be alert to the risk of drug interactions with tramadol
Link  MHRA: Warfarin: reports of calciphylaxis

View adult BNF  View SPC online  View childrens BNF
Acenocoumarol Sinthrome®
Formulary

Tablets 1mg

Second line vitamin K antagonist


Amber 0 View adult BNF  View SPC online  View childrens BNF
Andexanet alfa Ondexxya®
Formulary

Powder for solution for infusion 200mg

 

Link  LSCMMG - Andexanet alfa
Link  NICE TA697- Andexanet alfa for reversing anticoagulation from apixaban or rivaroxaban

Red View adult BNF  View SPC online  View childrens BNF
Idarucizumab® Praxbind
Formulary

Solution for injection/infusion 2.5 g/50 mL


Rapid reversal of anticoagulant effects of dabigatran  

Link  LSCMMG: Idarucizumab

Red View adult BNF  View SPC online  View childrens BNF