Lancashire and South Cumbria
Formulary
 
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21 Palliative Care Formulary

This chapter of the formulary is under continual development, please let the team know if you have any comments about the contents: mlcsu.lscformulary@nhs.net

For more information about the formulary development process, please see: https://www.lancsmmg.nhs.uk/lancashire-and-south-cumbria-icb-formulary-development/

21 Palliative Care Formulary Drugs

Alfentanil injection
Formulary

Palliative care

500micrograms/ml injection

Moderate to severe pain in palliative care patients with severe renal impairment or intolerance to other opioids.

Use on specialist advice only.


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Amitriptyline
Formulary

Palliative care

Neuropathic pain


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Bisacodyl
Formulary

Palliative care

Constipation


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Buprenorphine
Formulary

Palliative care

Pain.

Only for use in patients who are unable to take or tolerate oral medicine (including soluble tablets and liquids) OR where use of the low-dose buprenorphine patches may prevent administration problems for frail, elderly patients in the community.

 
Do not confuse the formulations of transdermal patches which are available in various strengths as 7-day, 4-day and 3-day patches; 3 day patches are not recommended to avoid confusion in dosing.
 
Always prescribe by brand name.
 
7 day transdermal patches: 5 microgram / hour, 10 microgram / hour, 15 microgram/hour, 20 microgram / hour (In primary care please prescribe as Sevodyne®, Butec® or Bunov®)
 
4 day transdermal patches are much stronger: 35 microgram/hour, 52.5 microgram/hour, 70 microgram/hour (In primary care please prescribe as Bupeaze®, Relevtec® or Carlosafine®)

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Celecoxib
Formulary

Palliative care

Pain: Anti-inflammatory


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Co-danthramer
Formulary

Palliative care

Constipation

Opiod-induced constipation


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Cyclizine
Formulary

Palliative care

Nausea and vomiting

Nausea and vomiting in the last days of life

Opioid-induced nausea and vomiting


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Dexamethasone
Formulary

Palliative care

Bowel obstruction - reduction of tumour oedema associated with bowel obstruction

Breathlessness

Corticosteroids in palliative care - Anorexia, Adjuvant analgesic, Nausea and vomiting associated with chemotherapy, Obstructive syndromes, Raised intracranial pressure, Spinal cord compression

Nausea and vomiting - raised Intracranial Pressure

Palliative care emergencies - SVC obstruction AND Metastatic spinal cord compression


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Diazepam
Formulary

Palliative care

Seizures


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Docusate
Formulary

Palliative care

Constipation

Opioid-induced constipation


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Domperidone
Formulary

Palliative care

Nausea and vomiting


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Duloxetine
Formulary

Palliative care

Neuropathic pain


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Esomeprazole injection
Formulary

Palliative care

(powder for reconstitution) - 40mg vial

Patients for whom parenteral administration of PPI is indicated for symptom control but for whom iv access is not possible.

May not be available from community pharmacies - check supply.


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Fentanyl
Formulary

Palliative care

Pain

Link  MHRA: Fentanyl skin patches: How to use and dispose of them safely
Link  MHRA: Serious and fatal overdose of fentanyl patches

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Fentanyl buccal tablets Effentora®
Formulary

Palliative care

Buccal tablets 100mcg, 200mcg, 400mcg, 600mcg, 800mcg

Pain.

For other preparations, see section 04.07.02.  Sublingual tablets are for use in palliative care only.


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Gabapentin
Formulary

Palliative care

Neuropathic pain


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Glycopyrronium
Formulary

Palliative care

Bowel obstruction - colic associated with bowel obstruction AND GI secretions associated with bowel obstruction

Respiratory tract secretions in the last days of life


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Haloperidol
Formulary

Palliative care

Care in the last weeks or days of life - Nausea and vomiting in the last days of life AND Agitation/terminal restlessness in the last days of life

Nausea and vomiting

Opioid-induced nausea and vomiting


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Hydromorphone
Formulary

Palliative care

Immediate release capsules 1.3mg, 2.6mg
Modified release capsules 2mg, 4mg, 8mg, 16mg, 24mg
Solution for injection for infusion 2mg/ml, 10mg/ml

Opioid rotation in patients with intolerable side effects or inadequate response to other opioids.


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Hyoscine butylbromide
Formulary

Palliative care

Bowel obstruction - colic associated with bowel obstruction AND GI secretions associated with bowel obstruction

Respiratory tract secretions in the last days of life


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Hyoscine hydrobromide
Formulary

Palliative care

Respiratory tract secretions in the last days of life


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Ibuprofen
Formulary

Palltiave care

Pain: Anti-inflammatory


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Ketamine
Formulary

Palliative care

Oral solution 50mg/5ml

Pain.


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Lactulose
Formulary

Palliative care

Constipation


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Levetiracetam
Formulary

Palliative care

Concentrate for solution for infusion 500mg/5ml

Management for prolonged seizures or status epilepticus in palliative and end of life care.


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Levomepromazine
Formulary

Palliative care

Care in the last weeks or days of life - Nausea and vomiting in the last days of life AND Agitation/terminal restlessness in the last days of life

Nausea and vomiting

Opioid-induced nausea and vomiting


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Lidocaine 5% medicated plasters
Formulary

Palliative care

5% medicated plasters

Complex neuropathic pain.


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Lorazepam
Formulary

Palliative care

Breathlessness

Breathlessness in the last days of life


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Methadone
Formulary

Palliative care

Tablets 5mg,
Injection 10mg/1mL, liquid 1mg/ml

Pain or cough.


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Metoclopramide
Formulary

Palliative care

Nausea and vomiting

Opioid-induced nausea and vomiting


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Midazolam
Formulary

Palliative care

Breathlessness

Care in the last weeks or days of life - Breathlessness in the last days of life AND Agitation/terminal restlessness in the last days of life

Palliative care emergencies - Seizures AND Anixolytic following major blood loss


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Morphine
Formulary

Palliative care 

Breathlessness

Pain in the last weeks or days of life

Breathlessness in the last days of life

Pain


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Morphine sulfate orodispersible tablets Actimorph®
Formulary

Palliative care

Orodispersible tablets (Actimorph) 1mg, 2.5mg, 5mg, 10mg, 20mg, 30mg


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Naloxegol
Formulary

Palliative care

Opioid-induced constipation


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Naproxen
Formulary

Palliative care

Pain: Anti-inflammatory


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Nefopam tablets
Formulary

Palliative care

30mg tablets

Pain in palliative care including in patients with liver failure.

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Octreotide
Formulary

Palliative care

Bowel obstruction - GI secretions associated with bowel obstruction. 


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Olanzapine
Formulary

Palliative care

Tablets, orodispersible tablets, powder for solution for injection

Nausea and vomiting, appetite stimulant.


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Ondansetron
Formulary

Palliative care

Bowel obstruction - nausea and vomiting associated with bowel obstruction


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Oxycodone
Formulary

Palliative care

Breathlessness in the last days of life (on the advice of a specialist)


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Oxygen
Formulary

Palliative care

Breathlessness


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Parecoxib
Formulary

Palliative care

40mg powder for solution for injection

Pain.


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Phenobarbital injection
Formulary

Palliative care

Injection 200mg / ml

Third line for patients who fail to respond to combined use of midazolam and anti psychotic (usually levomepromazine) for refractory agitation at the end of life.

Use on specialist advice only.


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Pregabalin
Formulary

Palliative care

Neuropathic pain


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Prochlorperazine (buccal)
Formulary

Palliative care

Nausea and vomiting in the last days of life


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Salbutamol 2.5mg nebules
Formulary

Palliative care

Breathlessness


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Senna
Formulary

Palliative care

Constipation

Opioid-induced constipation


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Sodium chloride 0.9% nebules
Formulary

Palliative care

Breathlessness


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