Lancashire and South Cumbria
Formulary
 
back
4 Central nervous system

This chapter of the formulary is under continual development, please let the team know if you have any comments about the contents: mlcsu.lscformulary@nhs.net

For more information about the formulary development process, please see: https://www.lancsmmg.nhs.uk/lancashire-and-south-cumbria-icb-formulary-development/

04-07-02 Opioid analgesics
For relief of moderate to severe pain
Buprenorphine
Formulary

SEVEN day patches only to be prescribed (brands are interchangeable)

Hospital prescriber to prescribe generically and contract patches to be supplied

(To be prescribed as Sevodyne patches in Primary Care - 5,10,15 and 20mcg/hr)

Only for use in patients who are unable to take or tolerate oral medicine (including soluble tablets and liquids) OR where use of the low-dose buprenorphine patches may prevent administration problems for frail, elderly patients in the Community.

 

Transdermal preparations lack the flexibility required when treating patients with fluctuating or uncontrolled pain. Use should be reserved for patients with stable pain who are unable to take or tolerate oral medicines. Buprenorphine patches are several times more expensive than equivalent doses of oral analgesics, and inappropriate use of transdermal preparations has cost implications for commissioners. It is recommended that the reason for using a patch is documented on initiation and, if appropriate, patients are switched to oral formulations at the earliest opportunity.

**Under review**


Controlled Drug  Green Restricted View adult BNF  View SPC online  View childrens BNF
Buprenorphine Temgesic®
Formulary

s/l tablets 200micrograms

See section 4.10 for products used in opioid dependence

**under review**


Controlled Drug  View adult BNF  View SPC online  View childrens BNF
Codeine Phosphate
Formulary
Tablets 15mg, 30mg
Injection 60mg/1mL
Syrup 25mg/5mL
Linctus, BP 15mg/5mL

Controlled Drug  Green View adult BNF  View SPC online  View childrens BNF
Diamorphine
Formulary

Injection 5mg, 10mg, 30mg, 100mg, 500mg

**under review**


Controlled Drug  View adult BNF  View SPC online  View childrens BNF
Dihydrocodeine
Formulary

Tablets 30mg

For use only in patients who are breastfeeding or after initiation by the pain team.  For short term use only.

**under review**


Controlled Drug  Green Restricted View adult BNF  View SPC online  View childrens BNF
Fentanyl
Formulary
Matrix patches 12, 25, 50, 75, 100micrograms/hour for 72hours
Sublingual tablets (AbstralŪ) 100microgram, 300 microgram, 400microgram, 600microgram, 800 microgram
Link  MHRA: Transdermal fentanyl patches: life-threatening and fatal opioid toxicity from accidental exposure, particularly in children

Controlled Drug  Green View adult BNF  View SPC online  View childrens BNF
Methadone
Formulary

Tablets 5mg
Injection 10mg/1mL

Methadone, when used as an analgesic, should be initiated by specialists in palliative care only

see section 4.10 for products used in opioid dependence

**under review**


Controlled Drug  View adult BNF  View SPC online  View childrens BNF
Morphine
Formulary

Check local guidance


Controlled Drug  Green View adult BNF  View SPC online  View childrens BNF
Oxycodone
Formulary

Check local guidance 

Oxycodone should be initiated by consultant physicians or specialists in palliative care only, it is indicated only for patients who do not tolerate morphine

 

**under review**


Controlled Drug  Green View adult BNF  View SPC online  View childrens BNF
Pethidine
Formulary
Injection 50mg/1mL

Controlled Drug  Red View adult BNF  View SPC online  View childrens BNF
Tapentadol Palexia®
Formulary

M/R tablets 50mg, 100mg, 150mg, 200mg, 250mg
 
Amber 
for palliative care
 
Black 
 In Morecambe Bay for other indications

**under review**

Link  MHRA: Tapentadol (Palexia): risk of seizures and reports of serotonin syndrome when co-administered with other medicines

Controlled Drug  View adult BNF  View SPC online  View childrens BNF
Tramadol
Formulary

Capsules 50mg
Dispersible tablets 50mg
m/r tablets 100mg, 200mg

Red Injection 100mg/2mL

Link  MHRA: Warfarin: be alert to the risk of drug interactions with tramadol

Controlled Drug  Green View adult BNF  View SPC online  View childrens BNF