Lancashire and South Cumbria
Formulary
 
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4 Central nervous system
04-09-01 Dopamine receptor agonists

Pramipexole
Formulary

Tablets 88micrograms, 180micrograms, 350 micrograms, 700micrograms pramipexole base (equivalent to 125micrograms, 250micrograms, 500micrograms and 1mg pramipexole salt)
Modified-release tablets 260 micrograms, 520 micrograms 1.05mg, 1.57mg, 2.1mg, 2.62mg, 3.15mg base (equivalent to 375micrograms, 750micrograms, 1.5mg, 2.25mg, 3mg, 3.75mg, 4.5mg salt)

Parkinson's disease.


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Pramipexole
Formulary

Tablets 88micrograms, 180micrograms, 350 micrograms, 700micrograms pramipexole base (equivalent to 125micrograms, 250micrograms, 500micrograms and 1mg pramipexole salt)

Restless leg syndrome.

Recommended as the first line pharmacological treatment for restless leg syndrome, in line with the LSCMMG Restless Legs Syndrome Guidance.

Link  LSCMMG: The Management of Restless Legs Syndrome in Adults in Primary Care

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Ropinirole
Formulary

Tablets 250micrograms, 500micrograms, 1mg, 2mg
Modified-release tablets 2mg, 3mg, 4mg, 6mg, 8mg

Parkinson's disease.

 

Link  MHRA: Recent drug-name confusion

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Ropinirole
Formulary

Tablets 250micrograms, 500micrograms, 1mg, 2mg

Restless leg syndrome.

Recommended as the second line pharmacological treatment for restless leg syndrome, in line with the LSCMMG Restless Legs Syndrome Guidance.

Link  MHRA: Recent drug-name confusion

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Rotigotine
Formulary

Patches 2mg/24 hours, 4mg/24 hours, 6mg/24 hours, 8mg/24 hours

Parkinson's Disease.

Rotigotine has shown inferiority to ropinirole and should not be used in preference to other dopamine agonists unless such alternative are not suitable (e.g. compliance issues, need for social care to administer other oral therapies, dysphagia), not tolerated (GI disturbance), or ineffective.


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Rotigotine
Formulary

Patches 1mg/24 hours, 2mg/24 hours, 3mg/24 hours

Restless Legs Syndrome.

Recommended for restricted use in line with the LSCMMG Restless Legs Syndrome Guidance.


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Apomorphine Dacepton®
Formulary

Injection 50mg/5mL

Pre-filled pen 30mg/3mL

Link  LSCMMG: Shared care guideline
Link  MHRA: Apomorphine with domperidone: minimising risk of cardiac side effects

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Amantadine
Formulary

Capsules 100mg
Liquid 50mg/5mL

Parkinson's disease (but not drug-induced extrapyramidal symptoms).


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