Lancashire and South Cumbria
Formulary
 
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4 Central nervous system
04-06 Domperidone and metoclopramide

Metoclopramide
Formulary

Tablets 10mg
Liquid 5mg/5ml
Injection 10mg/2mL

Metoclopramide can induce acute dystonic reactions involving facial and skeletal muscle spasms and oculogyric crises. These dystonic effects are more common in the young (especially girls and young women) and the very old.

Metoclopramide should only be prescribed for short-term use (up to 5 days).

Link  MHRA: Metoclopramide: risk of neurological adverse effects

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Domperidone
Formulary

Tablets 10mg
Liquid 5mg/5mL

Domperidone is no longer indicated for the relief of nausea and vomiting in children aged under 12 years or those weighing less than 35 kg.

Healthcare professionals are advised to adhere to the licensed dose and to use the lowest effective dose for the shortest possible duration (max. treatment duration should not usually exceed 1 week).

Link  MHRA: Apomorphine with domperidone: minimising risk of cardiac side effects
Link  MHRA: Domperidone for nausea and vomiting: lack of efficacy in children; reminder of contraindications in adults and adolescents
Link  MHRA: Domperidone: risks of cardiac side effects

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