Lancashire and South Cumbria
Formulary
Formulary
4 Central nervous system
04-06 5HT3 antagonists
| Ondansetron |
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Formulary
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Tablets 4mg, 8mg Nausea & vomiting post operatively or chemotherapy induced. |
 MHRA: Ondansetron for intravenous use: dose-dependent QT interval prolongation MHRA: Ondansetron: small increased risk of oral clefts following use in the first 12 weeks of pregnancy NICE: Management of vomiting in children and young people with gastroenteritis: ondansetron |
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| Granisetron |
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Formulary
|
Tablets 1mg Nausea & vomiting post operatively or chemotherapy induced. |
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| Ondansetron |
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Formulary
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Second line for hyperemesis (unlicensed indication) in line with RCOG guidance. |
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MHRA: Ondansetron for intravenous use: dose-dependent QT interval prolongation MHRA: Ondansetron: small increased risk of oral clefts following use in the first 12 weeks of pregnancy RCOG: The Management of Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum (Green-top Guideline No.69) |
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Links
- Hypersalivation – can hyoscine hydrobromide be used to treat it?
- Hypersalivation treatment options
- LSCMMG: Levomepromazine
- MHRA Drug Safety Update April 2016: Apomorphine with domperidone: minimising risk of cardiac side effects
- MHRA Drug Safety Update Dec 2019: Domperidone for nausea and vomiting: lack of efficacy in children; reminder of contraindications in adults and adolescents
- MHRA Dug Safety Update Jan 2020: Ondansetron in pregnancy – small increased risk of oral clefts following use in the first 12 weeks of pregnancy
- MHRA update on restricted dose information (Aug 13)
- MHRA: Advice for domperidone (April 2014)
- MHRA: Apomorphine with domperidone: minimising risk of cardiac side effects
- MHRA: Domperidone for nausea and vomiting: lack of efficacy in children; reminder of contraindications in adults and adolescents
- MHRA: Domperidone: risks of cardiac side effects
- MHRA: Hyoscine hydrobromide patches (Scopoderm 1.5mg Patch or Scopoderm TTS Patch): risk of anticholinergic side effects, including hyperthermia
- MHRA: Metoclopramide: risk of neurological adverse effects
- MHRA: Ondansetron for intravenous use: dose-dependent QT interval prolongation
- MHRA: Ondansetron for intravenous use: dose-dependent QT interval prolongation
- MHRA: Ondansetron: small increased risk of oral clefts following use in the first 12 weeks of pregnancy
- MHRA: Ondansetron: small increased risk of oral clefts following use in the first 12 weeks of pregnancy
- NICE CG150: Headaches in over 12s: diagnosis and management
- NICE TA:919 Rimegepant for treating migraine
- NICE: Management of vomiting in children and young people with gastroenteritis: ondansetron
- Ondansetron for vomiting in children with gastroenteritis- NICE evidence summary
- RCOG: The Management of Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum (Green-top Guideline No.69)
UKMI: Domperidone - New restrictions in GI conditions (May 2014)