Lancashire and South Cumbria
Formulary
 
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5 Infections

This chapter of the formulary is under development, please use local/national antimicrobial guidelines to support prescribing choices.

For more information about the formulary development process, please see: https://www.lancsmmg.nhs.uk/lancashire-and-south-cumbria-icb-formulary-development/
The formulary development team can be contacted here: mlcsu.lscformulary@nhs.net

Prescribers must follow the relevant local and national guidance when treating an infection. Some anti-infectives require approval from the local Trust microbiology team for use, consult local guidance for further information.

Not all anti-infectives listed in this chapter will be available in all localities; availability will be guided by local need and resistance patterns.

05-03 Antiviral drugs

Baricitinib
Formulary

Use in line with NG191.

Link  NICE NG191: COVID-19 rapid guideline: managing COVID-19

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Molnupiravir
Formulary

Use in line with NG191.

Link  NICE NG191: COVID-19 rapid guideline: managing COVID-19

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Nirmatrelvir with Ritonavir Paxlovid®
Formulary

Tablets 150mg/100mg

Link  LSCMMG: Nirmatrelvir plus ritonavir, sotrovimab and tocilizumab
Link  MHRA: COVID-19 antivirals: reporting to the UK COVID-19 Antivirals Pregnancy Registry
Link  MHRA: Nirmatrelvir, ritonavir (Paxlovid▼): be alert to the risk of drug interactions with ritonavir
Link  NICE TA878: Nirmatrelvir plus ritonavir, sotrovimab and tocilizumab for treating COVID-19

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Remdesivir Veklury®
Formulary

Concentrate for solution for infusion 100mg

Agreed as a pass through cost to the ICB.

Link  MHRA: COVID-19 antivirals: reporting to the UK COVID-19 Antivirals Pregnancy Registry
Link  NICE TA971: Remdesivir and tixagevimab plus cilgavimab for treating COVID-19

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Sotrovimab  Xevudy®
Formulary

Concentrate for solution for infusion
500mg

Link  LSCMMG: Nirmatrelvir plus ritonavir, sotrovimab and tocilizumab
Link  NICE TA878: Nirmatrelvir plus ritonavir, sotrovimab and tocilizumab for treating COVID-19

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Tocilizumab
Formulary

Infusion

Link  LSCMMG: Nirmatrelvir plus ritonavir, sotrovimab and tocilizumab
Link  MHRA: Tocilizumab (RoActemra): rare risk of serious liver injury including cases requiring transplantation
Link  NICE TA878: Nirmatrelvir plus ritonavir, sotrovimab and tocilizumab for treating COVID-19

Red View adult BNF  View SPC online  View childrens BNF