Lancashire and South Cumbria
Formulary
 
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5 Infections

 

Prescribers must follow the relevant local and national guidance when treating an infection. Some anti-infectives require approval from the local Trust microbiology team for use, consult local guidance for further information.

Not all anti-infectives listed in this chapter will be available in all localities; availability will be guided by local need and resistance patterns.

05-01-07 Fidaxomicin

Fidaxomicin
Formulary

Tablets 200mg

Treatment of Clostridium difficile infections (CDI) also known as C. difficile-associated diarrhoea (CDAD) in adults.

Fidaxomicin should be initiated by a microbiologist or under microbiologist recommendation.
Fidaxomicin (Dificlir®) to be considered as an option for use following a first or second relapse. i.e. as second or third line therapy.
Fidaxomicin to also be considered for patients with severe CDI who are considered to be at high risk for recurrence as per the Public Health England Guidance. e.g. elderly patients with multiple comorbidities who are receiving concomitant antibiotics and those not responding to oral vancomycin.


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