Lancashire and South Cumbria
Formulary
 
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6 Endocrine system
06-01-02-03 SGLT2 inhibitors

Canagliflozin Invokana®
Formulary

Tablets 100mg, 300mg

First line gliflozin

Link  MHRA Drug Safety Update Feb 2019: SGLT2 inhibitors: reports of Fournier’s gangrene (necrotising fasciitis of the genitalia or perineum)
Link  MHRA Drug Safety Update April 2016: SGLT2 inhibitors: updated advice on the risk of diabetic ketoacidosis
Link  MHRA Drug Safety Update March 2020: SGLT2 inhibitors: monitor ketones in blood during treatment interruption for surgical procedures or acute serious medical illness
Link  MHRA: SGLT2 inhibitors: updated advice on increased risk of lower-limb amputation (mainly toes)
Link  NICE TA315: Canagliflozin in combination therapy for treating type 2 diabetes
Link  NICE TA390: Canagliflozin, dapagliflozin and empagliflozin as monotherapies for treating type 2 diabetes

Green View adult BNF  View SPC online  View childrens BNF
Dapagliflozin Forxiga®
Formulary

Tablets 5mg, 10mg

First line gliflozin

Green ICB commissioned for NICE TA775 Dapagliflozin for treating chronic kidney disease 

Link  NICE TA775: Dapagliflozin for treating chronic kidney disease
Link  MHRA Drug safety Update Feb 2019: SGLT2 inhibitors: reports of Fournier’s gangrene (necrotising fasciitis of the genitalia or perineum)
Link  MHRA Drug Safety Update April 2016: SGLT2 inhibitors: updated advice on the risk of diabetic ketoacidosis
Link  MHRA Drug Safety Update December 2021: Dapagliflozin (Forxiga): no longer authorised for treatment of type 1 diabetes mellitus
Link  MHRA Drug Safety Update March 2020: SGLT2 inhibitors: monitor ketones in blood during treatment interruption for surgical procedures or acute serious medical illness
Link  MHRA: SGLT2 inhibitors: updated advice on increased risk of lower-limb amputation (mainly toes)
Link  NICE TA288: Dapagliflozin in combination therapy for treating type 2 diabetes
Link  NICE TA390: Canagliflozin, dapagliflozin and empagliflozin as monotherapies for treating type 2 diabetes
Link  NICE TA418: Dapagliflozin in triple therapy for treating type 2 diabetes

Green View adult BNF  View SPC online  View childrens BNF
Empagliflozin Jardiance®
Formulary

Tablets 10mg, 25 mg

First line gliflozin

Link  MHRA Drug Safety Update Feb 2019: SGLT2 inhibitors: reports of Fournier’s gangrene (necrotising fasciitis of the genitalia or perineum)
Link  MHRA Drug Safety Update April 2016: SGLT2 inhibitors: updated advice on the risk of diabetic ketoacidosis
Link  MHRA Drug Safety UpdateMarch 2020: SGLT2 inhibitors: monitor ketones in blood during treatment interruption for surgical procedures or acute serious medical illness
Link  MHRA: SGLT2 inhibitors: updated advice on increased risk of lower-limb amputation (mainly toes)
Link  NICE TA336: Empagliflozin in combination therapy for treating type 2 diabetes
Link  NICE TA390: Canagliflozin, dapagliflozin and empagliflozin as monotherapies for treating type 2 diabetes
Link  NICE TA942: Empagliflozin for treating chronic kidney disease

Green View adult BNF  View SPC online  View childrens BNF
Ertugliflozin  Steglatro®
Formulary

Tablets 5mg, 15mg

Restriction - only to be used as second line

 

Link  MHRA Drug Safety Update Feb 2019: SGLT2 inhibitors: reports of Fournier’s gangrene (necrotising fasciitis of the genitalia or perineum)
Link  MHRA Drug Safety update June 2015: SGLT2 inhibitors (canagliflozin, dapagliflozin, empagliflozin): risk of diabetic ketoacidosis
Link  MHRA Drug Safety Update March 2020: SGLT2 inhibitors: monitor ketones in blood during treatment interruption for surgical procedures or acute serious medical illness
Link  MHRA: SGLT2 inhibitors: updated advice on increased risk of lower-limb amputation (mainly toes)
Link  NICE TA572: Ertugliflozin as monotherapy or with metformin for treating type 2 diabetes

Green Restricted View adult BNF  View SPC online  View childrens BNF
Canagliflozin / metformin IR Vokanamet
Formulary

Do Not Prescribe View adult BNF  View SPC online  View childrens BNF