Lancashire and South Cumbria
Formulary
 
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7 Obstetrics, Gynaecology, and urinary-tract disorders
07-02-01 Topical HRT

Transdermal oestrogens are absorbed and should be used in the smallest effective amount and if required long term should be combined with an oral progestogen in women with an intact uterus. For low-dose vaginal oestrogen, a progesterone is not needed for endometrial protection, as systemic absorption of vaginal oestrogen is minimal.


Estradiol vaginal 10 microgram tablet
Formulary

Vaginal tablets 10microgram

Link  MHRA: Hormone replacement therapy (HRT): further information on the known increased risk of breast cancer with HRT and its persistence after stopping

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Estriol cream
Formulary

0.1% vaginal cream, 0.01% vaginal cream

Currently estriol vaginal cream can be prescribed in two forms:
 
· Estriol 0.1% (Ovestin®) cream which contains 0.5mg estriol per 0.5g application
· Estriol 0.01% (formerly Ortho-Gynest®) cream which contains 0.5mg estriol per 5ml application
 
Despite Ovestin® 0.1% cream being 10 times stronger, the amount of cream delivered per application is 10 times less than that of Estriol 0.01% cream, meaning that both creams deliver an identical amount of estriol per application, that being 0.5mg.
 
Contains nuts - contraindicated in patients with hypersensitivity to nuts

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Estriol pessaries
Formulary

0.03mg  pessaries, 0.5mg pessaries


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Oestrogens, Topical Estring®
Formulary

Only used in patients who can't use gel or patches.


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Prasterone
Formulary

Vulvovaginal or vaginal atrophy in postmenopausal women having moderate to severe symptoms.

Link  LSCMMG: Prasterone

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