Lancashire and South Cumbria
Formulary
 
back
8 Malignant disease and immunosuppression

The majority of systemic anti-cancer therapies are not listed in this formulary as they are included in either the Lancashire and South Cumbria Cancer Alliance SACT protocols or the Cancer Drugs Fund list, produced by NHSE. 

08-02-02 Corticosteroids and other immunosuppressants

Avacopan Tavneos®
Formulary

Hard Capsules, 10mg

Link  NICE TA825: Avacopan for treating severe active granulomatosis with polyangiitis or microscopic polyangiitis

Red View adult BNF  View SPC online  View childrens BNF
Ciclosporin Neoral®
Formulary

Capsules 25mg, 50mg, 100mg
Liquid 100mg/1mL
Concentrate for intravenous infusion 50mg/1mL

Prescribe by brand name for transplant patients.

For use in other indications see sections 01.05.03, 10.01.03, and 11.11.

Link  LSCMMG: Ciclosporin shared care guideline

Red View adult BNF  View SPC online  View childrens BNF
Pegcetacoplan  Aspaveli®
Formulary

Solution for infusion. Each 20 mL vial contains 1 080 mg of pegcetacoplan.

Link  NICE TA778: Pegcetacoplan for treating paroxysmal nocturnal haemoglobinuria

Red View adult BNF  View SPC online  View childrens BNF
Prednisolone
Formulary

Tablets 1mg, 5mg
e/c tablets 2.5mg

25mg tablets are classified as Do Not Prescribe
 
There is no evidence that e/c prednisolone reduces the risk of gastrointestinal side effects. Uncoated tablets should be prescribed first line together with a PPI if necessary.

Also see sections 10.01.02.02, 06.03.02, 01.05.02, 11.04.01.


Green View adult BNF  View SPC online  View childrens BNF
Ruxolitinib Jakavi®
Formulary
Treatment of acute graft versus host disease that responds inadequately to corticosteroids in people 12 years and over.
 
Ruxolitinib will be available via the Innovative Medicines Fund (IMF) from 21st March 2025 in line with these recommendations and according to a set of treatment criteria which translates the NICE recommendation into a clinical guide as to use in practice.
Link  NICE GID-TA11512: Ruxolitinib for treating acute graft versus host disease refractory to corticosteroids in people aged 12 and over

Red View adult BNF  View SPC online  View childrens BNF
Sirolimus Rapamune®
Formulary
Tablets 500micrograms, 1mg, 2mg

The 500 microgram tablet is not bioequivalent to the 1 mg and 2 mg tablets. Multiples of 500 microgram tablets should not be used as a substitute for other tablet strengths.
Link  MHRA: Sirolimus: different immunoassays for therapeutic drug monitoring—risk of incorrect dose adjustment
Link  NICE TA481: Immunosuppressive therapy for kidney transplant in adults
Link  NICE TA482: Immunosuppressive therapy for kidney transplant in children and young people

Red View adult BNF  View SPC online  View childrens BNF
Tacrolimus
Formulary

Brand name prescribing essential

For prophylaxis of graft rejection

Dailiport modified release oral capsules are recommended for all patients who are newly prescribed modified release tacrolimus for transplant rejection – RAG status RED for new patients
Please note:
Dailiport modified release capsules are not bioequivalent to Adoport immediate release capsules and do not replace Adoport capsules.
Existing patients using Advagraf modified release capsules will remain on Advagraf and are not routinely switched to Dailiport. If a prescriber considers that switching a patient to a different brand of oral tacrolimus would be of benefit, the change requires careful supervision and therapeutic monitoring by an appropriate specialist.

See section 13.05.03 for use in dermatology.

Link  LSCMMG: Position Statement Prescribing of Oral Tacrolimus
Link  MHRA: Oral tacrolimus products: reminder to prescribe and dispense by brand name only
Link  NICE TA481: Immunosuppressive therapy for kidney transplant in adults
Link  NICE TA482: Immunosuppressive therapy for kidney transplant in children and young people

Red View adult BNF  View SPC online  View childrens BNF
Voclosporin Lupkynis®
Formulary

Capsules 7.9mg

Link  NICE TA882: Voclosporin with mycophenolate mofetil for treating lupus nephritis

Red View adult BNF  View SPC online  View childrens BNF