Lancashire and South Cumbria
Formulary
 
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9 Nutrition and blood

This chapter of the formulary is under continual development, please let the team know if you have any comments about the contents: mlcsu.lscformulary@nhs.net. 

For more information about the formulary development process, please see: https://www.lancsmmg.nhs.uk/lancashire-and-south-cumbria-icb-formulary-development/

09-01-04 Drugs used in autoimmune thrombocytopenic purpura

Anagrelide Xagrid®
Formulary

Capsules 500 micrograms

Consultant haemtologist only

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Avatrombopag Doptelet®
Formulary

Tablets 20mg

 

Red  NICE TA853 for treating primary chronic immune thrombocytopenia - see link below
Link  NICE TA626: Avatrombopag for treating thrombocytopenia in people with chronic liver disease needing a planned invasive procedure
Link  NICE TA853: Avatrombopag for treating primary chronic immune thrombocytopenia

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Caplacizumab  Cablivi®
Formulary

10mg powder and solvent for solution for injection
Link  NICE TA667: Caplacizumab with plasma exchange and immunosuppression for treating acute acquired thrombotic thrombocytopenic purpura

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Eltrombopag Revolade®
Formulary

Tablets 25mg, 50mg

Consultant haematologist or specialist in hepatitis C therapy only
Link  MHRA: Eltrombopag (Revolade): reports of interference with bilirubin and creatinine test results
Link  NICE TA293: Eltrombopag for treating chronic immune thrombocytopenia
Link  NICE TA382: Eltrombopag for treating severe aplastic anaemia refractory to immunosuppressive therapy (terminated appraisal)

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Fostamatinib  TAVLESSE ®
Formulary

Film coated tablets, 100mg, 150mg
Link  NICE TA935: Fostamatinib for treating refractory chronic immune thrombocytopenia

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Lusutrombopag Mulpleo®
Formulary

Film coated tablets 3mg
Link  NICE TA617: Lusutrombopag for treating thrombocytopenia in people with chronic liver disease needing a planned invasive procedure

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Romiplostim Nplate®
Formulary

Injection 250 micrograms

Consultant haematologist only
Link  NICE TA221: Romiplostim for the treatment of chronic immune thrombocytopenia

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Rituximab idiopathic thrombocytopenia in adults
Formulary

Off-label use for the treatment of idiopathic thrombocytopenia in adults.

For use as an alternative 2nd line treatment in adults with ITP following failure of corticosteriod treatment or when corticosteroids and thrombopoietin receptor agonists are contraindicated

Treatment requires initiation and continuation and continuation by specialist haematology services

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