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 Formulary Chapter 4: Central nervous system - Full Chapter
04.06  Expand sub section  Drugs used in nausea and vertigo
04.06  Expand sub section  Vomiting during pregnancy
04.06  Expand sub section  Postoperative nausea and vomiting
04.06  Expand sub section  Motion sickness
04.06  Expand sub section  Other vestibular disorders to top
04.06  Expand sub section  Cytotoxic chemotherapy
04.06  Expand sub section  Palliative care
04.06  Expand sub section  Migraine
04.06  Expand sub section  Antihistamines
04.06  Expand sub section  Phenothiazines and related drugs to top
04.06  Expand sub section  Domperidone and metoclopramide
04.06  Expand sub section  5HT3 antagonists
Ondansetron
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Formulary
Green

Tablets 4mg, 8mg
Liquid 4mg/5mL
Injection 4mg/2mL, 8mg/4mL

Nausea & vomiting post operatively or chemotherapy induced.

 
Link  MHRA: Ondansetron for intravenous use: dose-dependent QT interval prolongation
Link  MHRA: Ondansetron: small increased risk of oral clefts following use in the first 12 weeks of pregnancy
Link  NICE: Management of vomiting in children and young people with gastroenteritis: ondansetron
 
Granisetron
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Formulary
Red

Tablets 1mg
Injection 1mg/1ml, 3mg/3ml

Nausea & vomiting post operatively or chemotherapy induced.
Second line 5HT3 anatagonist.

 
 
Ondansetron
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Formulary
Amber 0

Second line for hyperemesis (unlicensed indication) in line with RCOG guidance.
Consultant initiation only.

 
Link  MHRA: Ondansetron for intravenous use: dose-dependent QT interval prolongation
Link  MHRA: Ondansetron: small increased risk of oral clefts following use in the first 12 weeks of pregnancy
Link  RCOG: The Management of Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum (Green-top Guideline No.69)
 
04.06  Expand sub section  Neurokinin receptor antagonist
04.06  Expand sub section  Cannabinoid
04.06  Expand sub section  Hyoscine to top
04.06  Expand sub section  Other drugs for Ménière's disease
 ....
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
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Link to adult BNF
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Link to children's BNF
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Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG
Green Low Carbon

Low carbon footprint

Amber Medium Carbon

Medium carbon footprint

Red High carbon footprint

High carbon footprint

Traffic Light Status Information

Status Description

Green

Green: Appropriate for initiation and ongoing prescribing in both primary and secondary care. Generally, little or no routine drug monitoring is required.  

Green Restricted

Green (Restricted): Appropriate for initiation and ongoing prescribing in both primary and secondary care provided: Additional criteria specific to the medicine or device are met, or The medicine or device is used following the failure of other therapies as defined by the relevant LSCMMG pathway. Generally, little or no routine drug monitoring is required.   

Red

Red medicines: Medicine is supplied by the hospital for the duration of the treatment course. Primary care initiation or continuation of treatment is not recommended unless exceptional circumstances such as specialist GP. Red medicines are those where primary care prescribing is not recommended. These treatments should be initiated by specialists only and prescribing retained within secondary care. They require specialist knowledge, intensive monitoring, specific dose adjustments or further evaluation in use. If however, a primary care prescriber has particular specialist knowledge or experience of prescribing a particular drug for a particular patient it would not always be appropriate for them to expect to transfer that prescribing responsibility back to secondary care. There should be a specific reason and a specific risk agreement, protocol and service set up to support this. Primary care prescribers may prescribe RED medicines in exceptional circumstances to patients to ensure continuity of supply while arrangements are made to obtain ongoing supplies from secondary care.  

Amber 0

Amber level 0: Suitable for prescribing in primary care following recommendation or initiation by a specialist. Little or no specific monitoring required. Patient may need a regular review, but this would not exceed that required for other medicines routinely prescribed in primary care. Brief prescribing document or information sheet may be required. Primary care prescribers must be familiar with the drug to take on prescribing responsibility or must get the required information. When recommending or handing over care, specialists should ask primary care prescribers to take over prescribing responsibility, and should give enough information about the indication, dose, monitoring requirements, use outside product licence and any necessary dose adjustments to allow them to confidently prescribe.  

Amber 1

Amber level 1 (with shared care): Suitable for prescribing in primary care following recommendation or initiation by a specialist. Minimal monitoring required. Patient may need a regular review, but this would not exceed that required for other medicines routinely prescribed in primary care. Full prior agreement about patient’s on-going care must be reached under the shared care agreement. Primary care prescribers are advised not to take on prescribing of these medicines unless they have been adequately informed by letter of their responsibilities with regards monitoring, side effects and interactions and are happy to take on the prescribing responsibility. A copy of locally approved shared care guidelines should accompany this letter which outlines these responsibilities. Primary care prescribers should then tell secondary care of their intentions as soon as possible by letter so that arrangements can be made for the transfer of care.  

Amber 2

Amber level 2 (with shared care and enhanced service): Initiated by specialist and transferred to primary care following a successful initiation period. Significant monitoring required on an on-going basis. Full prior agreement about patient’s on-going care must be reached under the shared care agreement. Suitable for enhanced service. These medicines are considered suitable for GP prescribing following specialist initiation of therapy, as per shared care document which will be sent out with the request to prescribe, with on-going communication between the primary care prescriber and specialist. Amber Level 2 medicines require significant monitoring for which an enhanced service may be suitable. (Subject to local commissioning agreements).  

Do Not Prescribe

Do not prescribe: NOT recommended for use by the NHS in Lancashire and South Cumbria. Includes medicines that NICE has not recommended for use and terminated technology appraisals, unless there is a local need.  

Grey

Grey medicines: Medicines which have not yet been reviewed or are under the review process. GPs and specialists are recommended not to prescribe these drugs. This category includes drugs where funding has not yet been agreed.   

Multiple

Refer to local guidance.  

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